Effective Strategies for Tumors Affecting Chemopreventive Metabolism
نویسندگان
چکیده
منابع مشابه
Effective strategies for tumors affecting chemopreventive metabolism.
In this issue, Charles et al. (1) showed in vivo that cytokines secreted by tumors, such as interleukin-6, down-regulate the transcription of cytochrome P450 CYP3A4 in liver and consequently the metabolism of CYP3A4 substrates. Reduced metabolism of chemotherapeutic agents could be responsible for side effects observed for these agents. The investigators postulate that treatment of the inflamma...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2006
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-1752